Dataset Information

Age-differential sexual dimorphisms in CHD8-S62X-mutant mouse synapses and transcriptomes.

ABSTRACT: Chd8^+/N2373K mice with a human C-terminal-truncating mutation (N2373K) display autistic-like behaviors in juvenile and adult males but not in females. In contrast, Chd8^+/S62X mice with a human N-terminal-truncating mutation (S62X) display behavioral deficits in juvenile males (not females) and adult males and females, indicative of age-differential sexually dimorphic behaviors. Excitatory synaptic transmission is suppressed and enhanced in male and female Chd8^+/S62X juveniles, respectively, but similarly enhanced in adult male and female mutants. ASD-like transcriptomic changes are stronger in newborn and juvenile (but not adult) Chd8^+/S62X males but in newborn and adult (not juvenile) Chd8^+/S62X females. These results point to age-differential sexual dimorphisms in Chd8^+/S62X mice at synaptic and transcriptomic levels, in addition to the behavioral level.

SUBMITTER: Lee SY

PROVIDER: S-EPMC9978779 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature

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Age-differential sexual dimorphisms in CHD8-S62X-mutant mouse synapses and transcriptomes.

Lee Soo Yeon SY Kweon Hanseul H Kang Hyojin H Kim Eunjoon E

Frontiers in molecular neuroscience 20230216

Chd8+/N2373K mice with a human C-terminal-truncating mutation (N2373K) display autistic-like behaviors in juvenile and adult males but not in females. In contrast, Chd8+/S62X mice with a human N-terminal-truncating mutation (S62X) display behavioral deficits in juvenile males (not females) and adult males and females, indicative of age-differential sexually dimorphic behaviors. Excitatory synaptic transmission is suppressed and enhanced in male and female C ...[more]

PMID: 36873104

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Dataset Information

Age-differential sexual dimorphisms in CHD8-S62X-mutant mouse synapses and transcriptomes.

Publications

Age-differential sexual dimorphisms in CHD8-S62X-mutant mouse synapses and transcriptomes.

Similar Datasets

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