Untargeted metabolomic profiling of sepsis-induced cardiac dysfunction.

ABSTRACT:

Objective

Sepsis is a life-threatening condition secondary to infection that evolves into a dysregulated host response and is associated with acute organ dysfunction. Sepsis-induced cardiac dysfunction is one of the most complex organ failures to characterize. This study performed comprehensive metabolomic profiling that distinguished between septic patients with and without cardiac dysfunction.

Method

Plasma samples collected from 80 septic patients were analysed by untargeted liquid chromatography-mass spectrometry (LC-MS) metabolomics. Principal component analysis (PCA), partial least squares discrimination analysis (PLS-DA), and orthogonal partial least square discriminant analysis (OPLS-DA) were applied to analyse the metabolic model between septic patients with and wit

SUBMITTER: Cao Y 

PROVIDER: S-EPMC9978788 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature