Leg restlessness and hyperparathyroidism in Parkinson's disease, a further clue to RLS pathogenesis?

ABSTRACT:

Background

Non-motor manifestations are the main features of Parkinson's disease (PD). These have been associated with vitamin D abnormalities, but the role of parathormone (PTH) is still obscure. Among the non-motor symptoms of PD, the pathogenesis of restless leg syndrome (RLS) is still debated, but it has been associated with the vitamin D/PTH axis in other disease models. Our study deepens the association between vitamin D and PTH with the prevalence of non-motor symptoms of PD and explores such a relationship in patients reporting leg restlessness.

Methods

Fifty patients with PD were extensively investigated with motor and non-motor scales. Data on serum levels of vitamin D, PTH, and related metabolites were obtained, and patients were stratified as having vitamin D def

SUBMITTER: Marano M 

PROVIDER: S-EPMC9978794 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature