Elevated Methionine Flux Drives Pyroptosis Evasion in Persister Cancer Cells.

ABSTRACT: Induction of cell death represents a primary goal of most anticancer treatments. Despite the efficacy of such approaches, a small population of "persisters" develop evasion strategies to therapy-induced cell death. While previous studies have identified mechanisms of resistance to apoptosis, the mechanisms by which persisters dampen other forms of cell death, such as pyroptosis, remain to be elucidated. Pyroptosis is a form of inflammatory cell death that involves formation of membrane pores, ion gradient imbalance, water inflow, and membrane rupture. Herein, we investigate mechanisms by which cancer persisters resist pyroptosis, survive, then proliferate in the presence of tyrosine kinase inhibitors (TKI). Lung, prostate, and esophageal cancer persister cells remaining after treatments ex

SUBMITTER: El-Kenawi A 

PROVIDER: S-EPMC9978888 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature