Association of Intensive vs Standard Blood Pressure Control With Regional Changes in Cerebral Small Vessel Disease Biomarkers: Post Hoc Secondary Analysis of the SPRINT MIND Randomized Clinical Trial.

ABSTRACT:

Importance

Little is known about the associations of strict blood pressure (BP) control with microstructural changes in small vessel disease markers.

Objective

To investigate the regional associations of intensive vs standard BP control with small vessel disease biomarkers, such as white matter lesions (WMLs), fractional anisotropy (FA), mean diffusivity (MD), and cerebral blood flow (CBF).

Design, setting, and participants

The Systolic Blood Pressure Intervention Trial (SPRINT) is a multicenter randomized clinical trial that compared intensive systolic BP (SBP) control (SBP target <120 mm Hg) vs standard control (SBP target <140 mm Hg) among participants aged 50 years or older with hypertension and without diabetes or a history of stroke. The study began randomizatio

SUBMITTER: Rashid T 

PROVIDER: S-EPMC9978954 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature