Enriched environment promotes post-stroke angiogenesis through astrocytic interleukin-17A.

ABSTRACT:

Objective

Our previous studies have revealed that the protective effect of an enriched environment (EE) may be linked with astrocyte proliferation and angiogenesis. However, the relationship between astrocytes and angiogenesis under EE conditions still requires further study. The current research examined the neuroprotective effects of EE on angiogenesis in an astrocytic interleukin-17A (IL-17A)-dependent manner following cerebral ischemia/reperfusion (I/R) injury.

Methods

A rat model of ischemic stroke based on middle cerebral artery occlusion (MCAO) for 120 min followed by reperfusion was established, after which rats were housed in either EE or standard conditions. A set of behavior tests were conducted, including the modified neurological severity scores (mNSS) and the r

SUBMITTER: Chen X 

PROVIDER: S-EPMC9979086 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature