Design and construction of microbial cell factories based on systems biology.

ABSTRACT: Environmental sustainability is an increasingly important issue in industry. As an environmentally friendly and sustainable way, constructing microbial cell factories to produce all kinds of valuable products has attracted more and more attention. In the process of constructing microbial cell factories, systems biology plays a crucial role. This review summarizes the recent applications of systems biology in the design and construction of microbial cell factories from four perspectives, including functional genes/enzymes discovery, bottleneck pathways identification, strains tolerance improvement and design and construction of synthetic microbial consortia. Systems biology tools can be employed to identify functional genes/enzymes involved in the biosynthetic pathways of products. These di

SUBMITTER: Yan W 

PROVIDER: S-EPMC9979088 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature