A geospatial modeling approach to quantifying the risk of exposure to environmental chemical mixtures via a common molecular target.

ABSTRACT: In the real world, individuals are exposed to chemicals from sources that vary over space and time. However, traditional risk assessments based on in vivo animal studies typically use a chemical-by-chemical approach and apical disease endpoints. New approach methodologies (NAMs) in toxicology, such as in vitro high-throughput (HTS) assays generated in Tox21 and ToxCast, can more readily provide mechanistic chemical hazard information for chemicals with no existing data than in vivo methods. In this paper, we establish a workflow to assess the joint action of 41 modeled ambient chemical exposures in the air from the USA-wide National Air Toxics Assessment by integrating human exposures with hazard data from curated HTS (cHTS) assays to identify counties where exposure to the local chemical

SUBMITTER: Eccles KM 

PROVIDER: S-EPMC9979101 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature