Opioid medication use and blood DNA methylation: epigenome-wide association meta-analysis.
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ABSTRACT:
SUBMITTER: Lee M
PROVIDER: S-EPMC9979153 | biostudies-literature | 2022 Dec
REPOSITORIES: biostudies-literature
Publications
Opioid medication use and blood DNA methylation: epigenome-wide association meta-analysis.
Lee Mikyeong M Joehanes Roby R McCartney Daniel L DL Kho Minjung M Hüls Anke A Wyss Annah B AB Liu Chunyu C Walker Rosie M RM R Kardia Sharon L SL Wingo Thomas S TS Burkholder Adam A Ma Jiantao J Campbell Archie A Wingo Aliza P AP Huan Tianxiao T Sikdar Sinjini S Keshawarz Amena A Bennett David A DA Smith Jennifer A JA Evans Kathryn L KL Levy Daniel D London Stephanie J SJ
Epigenomics 20221201 23
<b>Aim:</b> To identify differential methylation related to prescribed opioid use. <b>Methods:</b> This study examined whether blood DNA methylation, measured using Illumina arrays, differs by recent opioid medication use in four population-based cohorts. We meta-analyzed results (282 users; 10,560 nonusers) using inverse-variance weighting. <b>Results:</b> Differential methylation (false discovery rate <0.05) was observed at six CpGs annotated to the following genes: <i>KIAA0226</i>, <i>CPLX2</ ...[more]
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