Optimal therapy for concomitant EGFR and TP53 mutated non-small cell lung cancer: a real-world study.

ABSTRACT:

Background

Non-small cell cancer (NSCLC) patients with concomitant epidermal growth factor receptor (EGFR) and TP53 mutations have a poor prognosis with the treatment of tyrosine kinase inhibitors (TKIs), and may benefit from a combination regimen preferentially. The present study aims to compare the benefits of EGFR-TKIs and its combination with antiangiogenic drugs or chemotherapy in patients with NSCLC harboring EGFR and TP53 co-mutation in a real-life setting.

Methods

This retrospective analysis included 124 patients with advanced NSCLC having concomitant EGFR and TP53 mutations, who underwent next-generation sequencing prior to treatment. Patients were classified into the EGFR-TKI group and combination therapy group. The primary end point of this study was progression-f

SUBMITTER: Sun H 

PROVIDER: S-EPMC9979422 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature