Amino acid substitutions in specific proteins correlate with farnesol unresponsiveness in Candida albicans.

ABSTRACT:

Background

The quorum-sensing molecule farnesol, in opportunistic yeast Candida albicans, modulates its dimorphic switch between yeast and hyphal forms, and biofilm formation. Although there is an increasing interest in farnesol as a potential antifungal drug, the molecular mechanism by which C. albicans responds to this molecule is still not fully understood.

Results

A comparative genomic analysis between C. albicans strains that are naturally unresponsive to 30 µM of farnesol on TYE plates at 37 °C versus responsive strains uncovered new molecular determinants involved in the response to farnesol. While no signature gene was identified, amino acid changes in specific proteins were shown to correlate with the unresponsiveness to farnesol, particularly with substitutions in

SUBMITTER: Mohammadi S 

PROVIDER: S-EPMC9979538 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature