Paraganglioma of the Head and Neck: A Review.

ABSTRACT:

Objective

To review the epidemiology, presentation, diagnosis, and management of head and neck paragangliomas.

Methods

A literature review of english language papers with focus on most current literature.

Results

Paragangliomas (PGLs) are a group of neuroendocrine tumors that arise in the parasympathetic or sympathetic ganglia. Head and neck PGLs (HNPGLs) comprise 65% to 70% of all PGLs and account for 0.6% of all head and neck cancers. The majority of HNPGLs are benign, and 6% to 19% of all HNPGLs develop metastasis outside the tumor site and significantly compromise survival. PGLs can have a familial etiology with germline sequence variations in different susceptibility genes, with the gene encoding succinate dehydrogenase being the most common sequence variation, o

SUBMITTER: Sandow L 

PROVIDER: S-EPMC9979593 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature