Surfactant-Mediated Solubilization of Myelin Figures: A Multistep Morphological Cascade.

ABSTRACT: Lamellar mesophases of insoluble lipids are readily solubilized by the micellar mesophases of soluble surfactants. This simple process underscores a broad array of biochemical methodologies, including purification, reconstitution, and crystallization of membrane proteins, as well as the isolation of detergent-resistant membrane fractions. Although much is now known about the thermodynamic driving forces of membrane solubilization, the kinetic pathways by which the surfactant alters vesicular mesophases are only beginning to be appreciated. Little is known about how these interactions affect the solubilization of more complex, multilamellar mesophases. Here, we investigate how a common zwitterionic detergent affects the solubilization of a smectic, multilamellar, cylindrical mesophase of li

SUBMITTER: Speer DJ 

PROVIDER: S-EPMC9979658 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature