Disruption of stem cell niche-confined R-spondin 3 expression leads to impaired hematopoiesis.

ABSTRACT: Self-renewal and differentiation of stem and progenitor cells are tightly regulated to ensure tissue homeostasis. This regulation is enabled both remotely by systemic circulating cues, such as cytokines and hormones, and locally by various niche-confined factors. R-spondin 3 (RSPO3) is one of the most potent enhancers of Wnt signaling, and its expression is usually restricted to the stem cell niche where it provides localized enhancement of Wnt signaling to regulate stem cell expansion and differentiation. Disruption of this niche-confined expression can disturb proper tissue organization and lead to cancers. Here, we investigate the consequences of disrupting the niche-restricted expression of RSPO3 in various tissues, including the hematopoietic system. We show that normal Rspo3 expressi

SUBMITTER: Kurtova AV 

PROVIDER: S-EPMC9979769 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature