Analysis of urine Raman spectra differences from patients with diabetes mellitus and renal pathologies.

ABSTRACT:

Background

Chronic kidney disease (CKD) poses a major public health burden. Diabetes mellitus (DM) is one of the major causes of CKD. In patients with DM, it can be difficult to differentiate diabetic kidney disease (DKD) from other causes of glomerular damage; it should not be assumed that all DM patients with decreased eGFR and/or proteinuria have DKD. Renal biopsy is the standard for definitive diagnosis, but other less invasive methods may provide clinical benefit. As previously reported, Raman spectroscopy of CKD patient urine with statistical and chemometric modeling may provide a novel, non-invasive methodology for discriminating between renal pathologies.

Methods

Urine samples were collected from renal biopsied and non-biopsied patients presenting with CKD secondary

SUBMITTER: Kavuru V 

PROVIDER: S-EPMC9979830 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature