The effects of acute hydrogen peroxide exposure on respiratory cilia motility and viability.

ABSTRACT: COVID-19 has seen the propagation of alternative remedies to treat respiratory disease, such as nebulization of hydrogen peroxide (H₂O₂). As H₂O₂ has known cytotoxicity, it was hypothesised that H₂O₂ inhalation would negatively impact respiratory cilia function. To test this hypothesis, mouse tracheal samples were incubated with different H₂O₂ concentrations (0.1-1%) then cilia motility, cilia generated flow, and cell death was assessed 0-120 min following H₂O₂ treatment. 0.1-0.2% H₂O₂ caused immediate depression of cilia motility and complete cessation of cilia generated flow. Higher H₂O₂ concentrations (≥0.5%) caused immediate complete

SUBMITTER: Francis R 

PROVIDER: S-EPMC9979836 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature