The effects of electronic nicotine vapor on voluntary alcohol consumption in female and male C57BL/6 J mice.

ABSTRACT:

Significance

Alcohol drinking and nicotine vaping often co-occur and dependence on both substances is common. However, the impact of nicotine vaping on alcohol consumption is not fully understood.

Methods

We examined the effects of nicotine vaping on ethanol drinking in female and male C57BL/6 J mice using an electronic nicotine delivery system and intermittent access two-bottle choice (IA-2BC) drinking. Mice were exposed to electronic nicotine vapor (3%) or propylene glycol/vegetable glycerol (PG/VG) control for 3 h sessions daily for 4 weeks and voluntary alcohol consumption was monitored. Nicotine vapor exposure was stopped and voluntary alcohol drinking was measured for a 2 week abstinence period. We also examined the effects of alcohol and nicotine on locomotion, temper

SUBMITTER: Echeveste Sanchez M 

PROVIDER: S-EPMC9979979 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature