Selective IL-27 production by intestinal regulatory T cells permits gut-specific regulation of Th17 immunity.

ABSTRACT: Regulatory T (Treg) cells are instrumental in establishing immunological tolerance. However, the precise effector mechanisms by which Treg cells control a specific type of immune response in a given tissue remains unresolved. By simultaneously studying Treg cells from different tissue origins under systemic autoimmunity, here we show that IL-27 is specifically produced by intestinal Treg cells to regulate Th17 immunity. Selectively increased intestinal Th17 responses in mice with Treg cell-specific IL-27 ablation led to exacerbated intestinal inflammation and colitis-associated cancer, but also helped protect against enteric bacterial infection. Furthermore, single-cell transcriptomic analysis has identified a CD83⁺TCF1⁺ Treg cell subset that is distinct from previous

SUBMITTER: Lin CH 

PROVIDER: S-EPMC9980002 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature