PANGEA: A New Gene Set Enrichment Tool for <i>Drosophila</i> and Common Research Organisms.

ABSTRACT: Gene set enrichment analysis (GSEA) plays an important role in large-scale data analysis, helping scientists discover the underlying biological patterns over-represented in a gene list resulting from, for example, an 'omics' study. Gene Ontology (GO) annotation is the most frequently used classification mechanism for gene set definition. Here we present a new GSEA tool, PANGEA (PAthway, Network and Gene-set Enrichment Analysis; https://www.flyrnai.org/tools/pangea/ ), developed to allow a more flexible and configurable approach to data analysis using a variety of classification sets. PANGEA allows GO analysis to be performed on different sets of GO annotations, for example excluding high-throughput studies. Beyond GO, gene sets for pathway annotation and protein complex data from various r

SUBMITTER: Hu Y 

PROVIDER: S-EPMC9980003 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature