Changes in the oral and nasal microbiota in pediatric obstructive sleep apnea

ABSTRACT: ABSTRACT

Background

Several clinical studies have demonstrated that pediatric obstructive sleep apnea (OSA) is associated with dysbiosis of airway mucosal microbiota. However, how oral and nasal microbial diversity, composition, and structure are altered in pediatric OSA has not been systemically explored.

Methods

30 polysomnography-confirmed OSA patients with adenoid hypertrophy, and 30 controls who did not have adenoid hypertrophy, were enrolled. Swabs from four surface oral tissue sites (tongue base, soft palate, both palatine tonsils, and adenoid) and one nasal swab from both anterior nares were collected. The 16S ribosomal RNA (rRNA) V3–V4 region was sequenced to identify the microbial communities.

Results

The beta diversity and microbial profiles were signi

SUBMITTER: Zhang X 

PROVIDER: S-EPMC9980019 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature