A latent clinical-anatomical dimension relating metabolic syndrome to brain structure and cognition.

ABSTRACT: The link between metabolic syndrome (MetS) and neurodegenerative as well cerebrovascular conditions holds substantial implications for brain health in at-risk populations. This study elucidates the complex relationship between MetS and brain health by conducting a comprehensive examination of cardiometabolic risk factors, cortical morphology, and cognitive function in 40,087 individuals. Multivariate, data-driven statistics identified a latent dimension linking more severe MetS to widespread brain morphological abnormalities, accounting for up to 71% of shared variance in the data. This dimension was replicable across sub-samples. In a mediation analysis we could demonstrate that MetS-related brain morphological abnormalities mediated the link between MetS severity and cognitive performanc

SUBMITTER: Petersen M 

PROVIDER: S-EPMC9980040 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature