Single neurons in the human medial temporal lobe flexibly shift representations across spatial and memory tasks.

ABSTRACT: Investigations into how individual neurons encode behavioral variables of interest have revealed specific representations in single neurons, such as place and object cells, as well as a wide range of cells with conjunctive encodings or mixed selectivity. However, as most experiments examine neural activity within individual tasks, it is currently unclear if and how neural representations change across different task contexts. Within this discussion, the medial temporal lobe is particularly salient, as it is known to be important for multiple behaviors including spatial navigation and memory, however the relationship between these functions is currently unclear. Here, to investigate how representations in single neurons vary across different task contexts in the MTL, we collected and analyz

SUBMITTER: Donoghue T 

PROVIDER: S-EPMC9980106 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature