Ontology highlight
ABSTRACT:
SUBMITTER: Feng Q
PROVIDER: S-EPMC9980208 | biostudies-literature | 2023 Feb
REPOSITORIES: biostudies-literature
Feng Qin Q Kim Hong H Barua Amrita A Huang Luping L Bolaji Modupeola M Zachariah Sharon S Jung Sung Yun SY He Bin B Zhou Tianyi T Mitra Aroshi A
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Prostate cancer is the most commonly diagnosed noncutaneous cancer in American men. TDRD1, a germ cell-specific gene, is erroneously expressed in more than half of prostate tumors, but its role in prostate cancer development remains elusive. In this study, we identified a PRMT5-TDRD1 signaling axis that regulates the proliferation of prostate cancer cells. PRMT5 is a protein arginine methyltransferase essential for small nuclear ribonucleoprotein (snRNP) biogenesis. Methylation of Sm proteins by ...[more]