Ontology highlight
ABSTRACT:
SUBMITTER: Ziegler N
PROVIDER: S-EPMC9980455 | biostudies-literature | 2023
REPOSITORIES: biostudies-literature
Ziegler Nicole N Cortés-López Mariela M Alt Francesca F Sprang Maximilian M Ustjanzew Arsenij A Lehmann Nadine N El Malki Khalifa K Wingerter Arthur A Russo Alexandra A Beck Olaf O Attig Sebastian S Roth Lea L König Julian J Paret Claudia C Faber Jörg J
Oncoimmunology 20230301 1
Despite massive improvements in the treatment of B-ALL through CART-19 immunotherapy, a large number of patients suffer a relapse due to loss of the targeted epitope. Mutations in the <i>CD19</i> locus and aberrant splicing events are known to account for the absence of surface antigen. However, early molecular determinants suggesting therapy resistance as well as the time point when first signs of epitope loss appear to be detectable are not enlightened so far. By deep sequencing of the <i>CD19 ...[more]