BECN1^F121A mutation increases autophagic flux in aged mice and improves aging phenotypes in an organ-dependent manner.

ABSTRACT: Macroautophagy/autophagy is necessary for lifespan extension in multiple model organisms and autophagy dysfunction impacts age-related phenotypes and diseases. Introduction of an F121A mutation into the essential autophagy protein BECN1 constitutively increases basal autophagy in young mice and reduces cardiac and renal age-related changes in longer lived Becn1^F121A mutant mice. However, both autophagic and lysosomal activities decline with age. Thus, whether autophagic flux is maintained during aging and whether it is enhanced in Becn1^F121A mice is unknown. Here, we demonstrate that old wild-type mice maintained functional autophagic flux in heart, kidney and skeletal muscle but not liver, and old Becn1^F121A mice h

SUBMITTER: Sebti S 

PROVIDER: S-EPMC9980460 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature