M⁶A RNA methylation regulators predict prognosis and indicate characteristics of tumour microenvironment infiltration in acute myeloid leukaemia.

ABSTRACT: Patients with acute myeloid leukaemia (AML) have poor prognoses and low overall survival (OS) rates owing to its heterogeneity and the complexity of its tumour microenvironment (TME). N6-methyladenosine (m⁶A) modification plays a key role in the initiation and progression of haematopoietic malignancies. However, the underlying function of m⁶A regulators in AML remains elusive. This study thoroughly analysed the m⁶A modification features of 177 AML patients based on 22 m⁶A regulators. Utilizing unsupervised clustering, we determined three distinct m⁶A modification patterns related to different biological functions, TME cell-infiltrating characteristics and clinical outcomes. Additionally, a risk score was constructed based on six m

SUBMITTER: Liao X 

PROVIDER: S-EPMC9980463 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature