Using fecal immmunochemical cartridges for gut microbiome analysis within a colorectal cancer screening program.

ABSTRACT: The colorectal cancer (CRC) screening program B-PREDICT is an invited two-stage screening project using a fecal immunochemical test (FIT) for initial screening followed by a colonoscopy for those with a positive FIT. Since the gut microbiome likely plays a role in the etiology of CRC, microbiome-based biomarkers in combination with FIT could be a promising tool for optimizing CRC screening. Therefore, we evaluated the usability of FIT cartridges for microbiome analysis and compared it to Stool Collection and Preservation Tubes. Corresponding FIT cartridges as well as Stool Collection and Preservation Tubes were collected from participants of the B-PREDICT screening program to perform 16S rRNA gene sequencing. We calculated intraclass correlation coefficients (ICCs) based on center log rati

SUBMITTER: Brezina S 

PROVIDER: S-EPMC9980522 | biostudies-literature | 2023 Jan-Dec

REPOSITORIES: biostudies-literature