Allogeneic hematopoietic cell transplantation, the microbiome, and graft-versus-host disease.

ABSTRACT: Many patients with hematological malignancies, such as acute myeloid leukemia, receive an allogeneic hematopoietic cell transplantation (HCT) to cure their underlying condition. Allogeneic HCT recipients are exposed to various elements during the pre-, peri- and post-transplant period that can disrupt intestinal microbiota, including chemo- and radiotherapy, antibiotics, and dietary changes. The dysbiotic post-HCT microbiome is characterized by low fecal microbial diversity, loss of anaerobic commensals, and intestinal domination, particularly by Enterococcus species, and is associated with poor transplant outcomes. Graft-versus-host disease (GvHD) is a frequent complication of allogeneic HCT caused by immunologic disparity between donor and host cells and results in tissue damage a

SUBMITTER: van Lier YF 

PROVIDER: S-EPMC9980553 | biostudies-literature | 2023 Jan-Dec

REPOSITORIES: biostudies-literature