Measles virus-imposed remodeling of the autophagy machinery determines the outcome of bacterial coinfection.

ABSTRACT: Although it is admitted that secondary infection can complicate viral diseases, the consequences of viral infection on cell susceptibility to other infections remain underexplored at the cellular level. We though to examine whether the sustained macroautophagy/autophagy associated with measles virus (MeV) infection could help cells oppose invasion by Salmonella Typhimurium, a bacterium sensitive to autophagic restriction. We report here the unexpected finding that Salmonella markedly replicated in MeV-infected cultures due to selective growth within multinucleated cells. Hyper-replicating Salmonella localized outside of LAMP1-positive compartments to an extent that equaled that of the predominantly cytosolic sifA mutant Salmonella. Bacteria were subjected

SUBMITTER: Claviere M 

PROVIDER: S-EPMC9980578 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature