Randomized controlled trial demonstrates response to a probiotic intervention for metabolic syndrome that may correspond to diet.

ABSTRACT: An individual's immune and metabolic status is coupled to their microbiome. Probiotics offer a promising, safe route to influence host health, possibly via the microbiome. Here, we report an 18-week, randomized prospective study that explores the effects of a probiotic vs. placebo supplement on 39 adults with elevated parameters of metabolic syndrome. We performed longitudinal sampling of stool and blood to profile the human microbiome and immune system. While we did not see changes in metabolic syndrome markers in response to the probiotic across the entire cohort, there were significant improvements in triglycerides and diastolic blood pressure in a subset of probiotic arm participants. Conversely, the non-responders had increased blood glucose and insulin levels over time. The responder

SUBMITTER: Wastyk HC 

PROVIDER: S-EPMC9980610 | biostudies-literature | 2023 Jan-Dec

REPOSITORIES: biostudies-literature