The role of anillin/Mid1p during medial division and cytokinesis: from fission yeast to cancer cells.

ABSTRACT: Cytokinesis is the final stage of cell division cycle when cellular constituents are separated to produce two daughter cells. This process is driven by the formation and constriction of a contractile ring. Progression of these events is controlled by mechanisms and proteins that are evolutionary conserved in eukaryotes from fungi to humans. Genetic and molecular studies in different model organisms identified essential cytokinesis genes, with several conserved proteins, including the anillin/Mid1p proteins, constituting the core cytokinetic machinery. The fission yeast Schizosaccharomyces pombe represents a well-established model organism to study eukaryotic cell cycle regulation. Cytokinesis in fission yeast and mammalian cells depends on the placement, assembly, maturation, and co

SUBMITTER: Rezig IM 

PROVIDER: S-EPMC9980708 | biostudies-literature | 2023 Mar-Mar

REPOSITORIES: biostudies-literature