Radiation-induced alterations in multi-layered, in-vitro skin models detected by optical coherence tomography and histological methods.

ABSTRACT:

Background

Inflammatory skin reactions and skin alterations are still a potential side effect in radiation therapy (RT), which also need attention for patients' health care.

Method

In a pre-clinical study we consider alterations in irradiated in-vitro skin models of epidermal and dermal layers. Typical dose regimes in radiation therapy are applied for irradiation. For non-invasive imaging and characterization optical coherence tomography (OCT) is used. Histological staining method is additionally applied for comparison and discussion.

Results

Structural features, such as keratinization, modifications in epidermal cell layer thickness and disorder in the layering-as indications for reactions to ionizing radiation and aging-could be observed by means of OCT and confirme

SUBMITTER: Bromberger L 

PROVIDER: S-EPMC9980765 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature