Autologous dendritic cell vaccination against HIV-1 induces changes in natural killer cell phenotype and functionality.

ABSTRACT: Although natural killer (NK) cells have been studied in connection with dendritic cell (DC)-based vaccination in the field of cancer immunology, their role has barely been addressed in the context of therapeutic vaccination against HIV-1. In this study, we evaluated whether a therapeutic DC-based vaccine consisting of monocyte-derived DCs electroporated with Tat, Rev and Nef encoding mRNA affects NK cell frequency, phenotype and functionality in HIV-1-infected individuals. Although the frequency of total NK cells did not change, we observed a significant increase in cytotoxic NK cells following immunisation. In addition, significant changes in the NK cell phenotype associated with migration and exhaustion were observed together with increased NK cell-mediated killing and (poly)functionalit

SUBMITTER: Laeremans T 

PROVIDER: S-EPMC9980861 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature