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Germinal center B cells that acquire nuclear proteins are specifically suppressed by follicular regulatory T cells.

ABSTRACT: Follicular regulatory T cells (Tfr) restrict development of autoantibodies and autoimmunity while supporting high-affinity foreign antigen-specific humoral response. However, whether Tfr can directly repress germinal center (GC) B cells that acquire autoantigens is unclear. Moreover, TCR specificity of Tfr to self-antigens is not known. Our study suggests that nuclear proteins contain antigens specific to Tfr. Targeting of these proteins to antigen-specific B cells in mice triggers rapid accumulation of Tfr with immunosuppressive characteristics. Tfr then exert negative regulation of GC B cells with predominant inhibition of the nuclear protein-acquiring GC B cells, suggesting an important role of direct cognate Tfr-GC B cells interactions for the control of effector B cell response.

SUBMITTER: Ke F

PROVIDER: S-EPMC9981149 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature

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Germinal center B cells that acquire nuclear proteins are specifically suppressed by follicular regulatory T cells.

Ke Fang F Benet Zachary L ZL Maz Mitra P MP Liu Jianhua J Dent Alexander L AL Kahlenberg Joanne Michelle JM Grigorova Irina L IL

eLife 20230302

Follicular regulatory T cells (Tfr) restrict development of autoantibodies and autoimmunity while supporting high-affinity foreign antigen-specific humoral response. However, whether Tfr can directly repress germinal center (GC) B cells that acquire autoantigens is unclear. Moreover, TCR specificity of Tfr to self-antigens is not known. Our study suggests that nuclear proteins contain antigens specific to Tfr. Targeting of these proteins to antigen-specific B cells in mice triggers rapid accumul ...[more]

PMID: 36862132

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