Are Standardized Tests Sensitive to Early Cognitive Change in Parkinson's Disease?

ABSTRACT:

Introduction

Cognitive deficits within the first years of Parkinson's disease (PD) diagnosis are commonly reported, and progression to dementia greatly impacts independence. Identifying measures sensitive to early changes is critical for trials of symptomatic therapies and neuroprotection.

Methods

A sample of 253 newly diagnosed PD patients and 134 Health Controls (HC) completed a brief cognitive battery annually over a 5-year period through the Parkinson's Progression Markers Initiative (PPMI). The battery included standardized measures of memory, visuospatial functions, processing speed, working memory, and verbal fluency. Inclusion criterion for HCs was performance above a cutoff for possible Mild Cognitive Impairment (pMCI) on cognitive screening (MoCA ⩾ 27) The PD sampl

SUBMITTER: Turner TH 

PROVIDER: S-EPMC9981339 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature