Serial Urinary C-C Motif Chemokine Ligand 14 and Risk of Persistent Severe Acute Kidney Injury.

ABSTRACT: To assess the added prognostic value of serial monitoring of urinary C-C motif chemokine ligand 14 (uCCL14) over that of single measurements, which have been shown to be prognostic for development of persistent severe acute kidney injury (AKI) in critically ill patients.

Design

Retrospective observational study.

Setting

Data derived from two multinational ICU studies (Ruby and Sapphire).

Patients

Critically ill patients with early stage 2-3 AKI.

Interventions

None.

Measurements and main results

We analyzed three consecutive uCCL14 measurements at 12-hour intervals after diagnosis of stage 2-3 AKI by Kidney Disease Improving Global Outcomes criteria. Primary outcome was persistent severe AKI, defined as 72 consecutive hours of stage 3 AKI, death, or receip

SUBMITTER: Prowle JR 

PROVIDER: S-EPMC9981369 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature