Elucidating the potential pharmaceutical mechanism of Gyejibokryeong-hwan on rosacea using network analysis.

ABSTRACT: Rosacea is a chronic erythematous disease with telangiectasia that affects the central area of the face. However, because of the ambiguity in the pathophysiology of rosacea, its treatment has not been clearly elucidated; therefore, new therapeutic options need to be developed. Gyejibokryeong-hwan (GBH) is widely used in clinical practice for various blood circulation disorders, including hot flushes. Therefore, we explored the potential pharmaceutical mechanism of GBH on rosacea and investigated the therapeutic points exclusive to GBH through comparative analysis with chemical drugs recommended in 4 guidelines for rosacea based on network analysis. The active compounds in GBH were identified, and the proteins targeted by these compounds and the genes related to rosacea were searched. Addit

SUBMITTER: Kim J 

PROVIDER: S-EPMC9981404 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature