The role of ferroptosis-related genes in airway epithelial cells of asthmatic patients based on bioinformatics.

ABSTRACT: It has been reported that airway epithelial cells and ferroptosis have certain effect on asthma. However, the action mechanism of ferroptosis-related genes in airway epithelial cells of asthmatic patients is still unclear. Firstly, the study downloaded the GSE43696 training set, GSE63142 validation set and GSE164119 (miRNA) dataset from the gene expression omnibus database. 342 ferroptosis-related genes were downloaded from the ferroptosis database. Moreover, differentially expressed genes (DEGs) between asthma and control samples in the GSE43696 dataset were screened by differential analysis. Consensus clustering analysis was performed on asthma patients to classify clusters, and differential analysis was performed on clusters to obtain inter-cluster DEGs. Asthma-related module was screen

SUBMITTER: Zheng Y 

PROVIDER: S-EPMC9981416 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature