Identification of STAT5B as a biomarker associated with prognosis and immune infiltration in breast cancer.

ABSTRACT:

Background

Breast invasive cancer (BRCA) is the most common malignancy and the second leading cause of malignancy death among women. Signal transducers and activators of transcription (STAT) family played a vital role in regulating certain biological processes and could serve as biomarkers for many diseases or cancers.

Methods

The expression, prognostic value, and clinical functions of STAT family in BRCA were evaluated with several bioinformatics web portals.

Results

The expression of STAT5A/5B were downregulated in BRCA in subgroup analyses based on race, age, gender, race, subclasses, tumor histology, menopause status, nodal metastasis status, and TP53 mutation. BRCA patients with high STAT5B expression had a better overall survival, relapse free survival, MDFS and

SUBMITTER: Li J 

PROVIDER: S-EPMC9981440 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature