Collateralizing ventral subiculum melanocortin 4 receptor circuits regulate energy balance and food motivation.

ABSTRACT: Hippocampal dysfunction is associated with major depressive disorder, a serious mental illness characterized by not only depressed mood but also appetite disturbance and dysregulated body weight. However, the underlying mechanisms by which hippocampal circuits regulate metabolic homeostasis remain incompletely understood. Here we show that collateralizing melanocortin 4 receptor (MC4R) circuits in the ventral subiculum (vSUB), one of the major output structures of the hippocampal formation, affect food motivation and energy balance. Viral-mediated cell type- and projection-specific input-output circuit mapping revealed that the nucleus accumbens shell (NAcSh)-projecting vSUB^MC4R+ neurons send extensive collateral projections of to various hypothalamic nuclei known to

SUBMITTER: Singh U 

PROVIDER: S-EPMC9981473 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature