Exposure to diverse sarbecoviruses indicates frequent zoonotic spillover in human communities interacting with wildlife.

ABSTRACT:

Background

Sarbecoviruses are a subgenus of Coronaviridae that mostly infect bats with known potential to infect humans (SARS-CoV and SARS-CoV-2). Populations in Southeast Asia, where these viruses are most likely to emerge, have been undersurveyed to date.

Methods

We surveyed communities engaged in extractive industries and bat guano harvesting from rural areas in Myanmar. Participants were screened for exposure to sarbecoviruses, and their interactions with wildlife were evaluated to determine the factors associated with exposure to sarbecoviruses.

Results

Of 693 people screened between July 2017 and February 2020, 12.1% were seropositive for sarbecoviruses. Individuals were significantly more likely to have been exposed to sarbecoviruses if their main livelihood in

SUBMITTER: Evans TS 

PROVIDER: S-EPMC9981523 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature