A comparative study of smart nanoformulations of diethyldithiocarbamate with Cu₄O₃ nanoparticles or zinc oxide nanoparticles for efficient eradication of metastatic breast cancer.

ABSTRACT: Metastatic tumor is initiated by metastatic seeds (cancer stem cells "CSCs") in a controlled redox microenvironment. Hence, an effective therapy that disrupts redox balance with eliminating CSCs is critical. Diethyldithiocarbamate (DE) is potent inhibitor of radical detoxifying enzyme (aldehyde dehydrogenase "ALDH"1A) causing effective eradication of CSCs. This DE effect was augmented and more selective by its nanoformulating with green synthesized copper oxide (Cu₄O₃) nanoparticles (NPs) and zinc oxide NPs, forming novel nanocomplexes of CD NPs and ZD NPs, respectively. These nanocomplexes exhibited the highest apoptotic, anti-migration, and ALDH1A inhibition potentials in M.D. Anderson-metastatic breast (MDA-MB) 231 cells. Importantly, these nanocomplexes revealed m

SUBMITTER: Abu-Serie MM 

PROVIDER: S-EPMC9981580 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature