Visuomotor anomalies in achiasmatic mice expressing a transfer-defective Vax1 mutant.

ABSTRACT: In binocular animals that exhibit stereoscopic visual responses, the axons of retinal ganglion cells (RGCs) connect to brain areas bilaterally by forming a commissure called the optic chiasm (OC). Ventral anterior homeobox 1 (Vax1) contributes to the formation of the OC, acting endogenously in optic pathway cells and exogenously in growing RGC axons. Here, we generated Vax1^AA/AA mice expressing the Vax1^AA mutant, which is incapable of intercellular transfer. We found that RGC axons cannot take up Vax1^AA protein from the Vax1^AA/AA mouse optic stalk (OS) and grow slowly to arrive at the hypothalamus at a late stage. The RGC axons of Vax1^AA/AA mice connect exclusively to ipsilateral brain areas after failing to access the midline, resulti

SUBMITTER: Min KW 

PROVIDER: S-EPMC9981622 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature