Inhaled milrinone in cardiac surgical patients: pharmacokinetic and pharmacodynamic exploration.

ABSTRACT: Mean arterial pressure to mean pulmonary arterial pressure ratio (mAP/mPAP) has been identified as a strong predictor of perioperative complications in cardiac surgery. We therefore investigated the pharmacokinetic/pharmacodynamic (PK/PD) relationship of inhaled milrinone in these patients using this ratio (R) as a PD marker. Following approval by the ethics and research committee and informed consent, we performed the following experiment. Before initiation of cardiopulmonary bypass in 28 pulmonary hypertensive patients scheduled for cardiac surgery, milrinone (5 mg) was nebulized, plasma concentrations measured (up to 10 h) and compartmental PK analysis carried out. Baseline (R₀) and peak (R_max) ratios as well as magnitude of peak response (∆_Rmax-R0) were

SUBMITTER: Nguyen AQ 

PROVIDER: S-EPMC9981759 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature