Tissue transglutaminase exacerbates renal fibrosis via alternative activation of monocyte-derived macrophages.

ABSTRACT: Macrophages are important components in modulating homeostatic and inflammatory responses and are generally categorized into two broad but distinct subsets: classical activated (M1) and alternatively activated (M2) depending on the microenvironment. Fibrosis is a chronic inflammatory disease exacerbated by M2 macrophages, although the detailed mechanism by which M2 macrophage polarization is regulated remains unclear. These polarization mechanisms have little in common between mice and humans, making it difficult to adapt research results obtained in mice to human diseases. Tissue transglutaminase (TG2) is a known marker common to mouse and human M2 macrophages and is a multifunctional enzyme responsible for crosslinking reactions. Here we sought to identify the role of TG2 in macrophage p

SUBMITTER: Shinoda Y 

PROVIDER: S-EPMC9981766 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature