Glycolysis-enhancing α₁-adrenergic antagonists modify cognitive symptoms related to Parkinson's disease.

ABSTRACT: Terazosin is an α₁-adrenergic receptor antagonist that enhances glycolysis and increases cellular ATP by binding to the enzyme phosphoglycerate kinase 1 (PGK1). Recent work has shown that terazosin is protective against motor dysfunction in rodent models of Parkinson's disease (PD) and is associated with slowed motor symptom progression in PD patients. However, PD is also characterized by profound cognitive symptoms. We tested the hypothesis that terazosin protects against cognitive symptoms associated with PD. We report two main results. First, in rodents with ventral tegmental area (VTA) dopamine depletion modeling aspects of PD-related cognitive dysfunction, we found that terazosin preserved cognitive function. Second, we found that after matching for demographics, comorbidit

SUBMITTER: Weber MA 

PROVIDER: S-EPMC9981768 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature