Longitudinal changes in neural gain and its relationship to cognitive control trajectory in young adults with early psychosis.

ABSTRACT: The mixed cognitive outcomes in early psychosis (EP) have important implications for recovery. In this longitudinal study, we asked whether baseline differences in the cognitive control system (CCS) in EP participants would revert toward a normative trajectory seen in healthy controls (HC). Thirty EP and 30 HC undertook functional MRI at baseline using the multi-source interference task-a paradigm that selectively introduces stimulus conflict-and 19 in each group repeated the task at 12 months. Activation of the left superior parietal cortex normalized over time for the EP group, relative to HC, coincident with improvements in reaction time and social-occupational functioning. To examine these group and timepoint differences, we used dynamic causal modeling to infer changes in effective co

SUBMITTER: Burgher B 

PROVIDER: S-EPMC9981770 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature