Increased nuchal translucency in children with congenital heart defects and normal karyotype-is there a correlation with mortality?

ABSTRACT:

Objectives

Our objective was to investigate if an increased nuchal translucency (NT) was associated with higher mortality in chromosomally normal children with congenital heart defects (CHD).

Methods

In a nationwide cohort using population-based registers, we identified 5,633 liveborn children in Denmark with a pre- or postnatal diagnosis of CHD from 2008 to 2018 (incidence of CHD 0.7%). Children with chromosomal abnormalities and non-singletons were excluded. The final cohort compromised 4,469 children. An increased NT was defined as NT > 95th-centile. Children with a NT > 95th-centile vs. NT < 95th-centile including subgroups of simple- and complex CHD were compared. Mortality was defined as death from natural causes, and mortalities were compared among groups. Survival an

SUBMITTER: Kristensen R 

PROVIDER: S-EPMC9981958 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature