Association of cytotoxic T-lymphocyte-associated protein 4 polymorphisms with recurrent pregnancy loss: A case-control study.

ABSTRACT:

Background

A large proportion of cases of recurrent pregnancy loss (RPL) are associated with immunological factors.

Objective

This study investigated the association between single nucleotide polymorphisms of cytotoxic T-lymphocyte-associated protein (CTLA)-4 gene in women with a history of RPL compared to healthy women.

Materials and methods

A case-control study was performed on 2 groups consisting of 120 healthy women with no history of abortion and at least one delivery (control) and 120 women with a history of 2 or more primary RPLs (case). In addition, 5 mL of peripheral blood sample was taken from all subjects. The frequencies of CTLA-4 rs3087243 and rs231775 polymorphisms were assayed by restriction fragment length polymorphism polymerase chain reaction

SUBMITTER: Vaziri Nezamdoust F 

PROVIDER: S-EPMC9982320 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature