Group 2 Innate Lymphoid Cells Protect Mice from Abdominal Aortic Aneurysm Formation via IL5 and Eosinophils.

ABSTRACT: Development of abdominal aortic aneurysms (AAA) enhances lesion group-2 innate lymphoid cell (ILC2) accumulation and blood IL5. ILC2 deficiency in Rora^fl/fl Il7r^Cre/+ mice or induced ILC2 depletion in Icos^fl-DTR-fl/+ Cd4^Cre/+ mice expedites AAA growth, increases lesion inflammation, but leads to systemic IL5 and eosinophil (EOS) deficiency. Mechanistic studies show that ILC2 protect mice from AAA formation via IL5 and EOS. IL5 or ILC2 from wild-type (WT) mice, but not ILC2 from Il5^-/- mice induces EOS differentiation in bone-marrow cells from Rora^fl/fl Il7r^Cre/+ mice. IL5, IL13, and EOS or ILC2 from WT mice, but not ILC2 from Il5^-/- and Il13^-/- mice block SMC apoptosis and promote SMC prolife

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC9982556 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature